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Series GSE83719 Query DataSets for GSE83719
Status Public on May 17, 2017
Title Transcriptome profiling of hematopoietic cells derived from human pluripotent stem cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We performed morphogen-directed differentiation of human PSCs into HE followed by combinatorial screening of 26 candidate HSC-specifying TFs for the potential to promote hematopoietic engraftment in irradiated immune deficient murine hosts. We recovered seven TFs (ERG, HOXA5, HOXA9, HOXA10, LCOR, RUNX1, SPI1) that together were sufficient to convert HE into hematopoietic stem and progenitor cells (HSPCs) that engraft primary and secondary murine recipients.
Overall design Hematopoietic cells derived from human pluripotent stem cells
Contributor(s) Sugimura R, Daley G
Citation(s) 28514439
Submission date Jun 25, 2016
Last update date May 15, 2019
Contact name Areum Han
Organization name Boston Children's Hospital
Lab Daley lab
Street address Karp Family Building, 7th Floor. 300 Longwood Ave.
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (5)
GSM2214010 HSPC from hiPSC_RS1
GSM2214011 HSPC from CB_RS2
GSM2214012 HE from hiPSC_RS3
This SubSeries is part of SuperSeries:
GSE85112 Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells via Transcription Factor Conversion of Hemogenic Endothelium
BioProject PRJNA326819
SRA SRP077096

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83719_RPKMvalues.txt.gz 670.3 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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