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Series GSE83675 Query DataSets for GSE83675
Status Public on Jun 30, 2017
Title Development of gene expression signatures of ascending aorta of the patients with bicuspid aortic valve compared to tricuspid aortic valve.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Bicuspid aortic valve is well known as a risk factor of dilation of ascending aorta. But the mechanisms of dialation are unknown. Morever, patients with bicuspid aortic valve tend to be aortic valve disease at younger age. After aortic valve surgery, if ascending aorta is dilated, the patient must be performed re-operation. For that reason, surgery for aortic root or ascending aorta is recommended to patient with bicuspid aortic valve with dilated ascending aorta. We thought that abnormality of cell cycle of the structure protein participated in ascending aorta dilation of patient with bicuspid aortic valve. We resected the wall of the ascending aota from patient undergoing aortic valve replacement for aortic valve stenosis during operation, and performed immunohistochemical staining for akt. Anti Akt antibodys were stained much on aortic media with bicuspoed aortic valve. Akt is a protein that is involved in mTOR / PI3K, and modulate the cell differenciation and proliferation. Further, the same samples were analyzed using a microarray method. On bicuspid aortic valve patients, the expression of TSC2 is reduced, and GβL is increased. TSC2 inhibit this pathway, and MLST8 activate this pathway. In the ascending aorta of BAV patients, PI3K / mTOR system is considered to be activated. When this pathway is activated, cell proliferation and cytodifferentiation are promoted abnormally,
Overall design The aortic valve replacement surgery, excised the ascending aorta wall of aortotomy site, was used as a sample. We divided into 2 groups(bicuspid aortic valve vs tricuspid aortic valve) and analysed.
Contributor(s) Hirata Y, Aoki H
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Submission date Jun 23, 2016
Last update date Jan 09, 2018
Contact name Yuuichirou Hirata
Organization name Kurume University School of Medicine
Department Department of Surgery
Street address 67 Asahimachi
City Kurume
ZIP/Postal code 830-0011
Country Japan
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (16)
GSM2212446 patient3
GSM2212447 patient12
GSM2212448 patient15
BioProject PRJNA326759

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83675_RAW.tar 198.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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