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Series GSE83612 Query DataSets for GSE83612
Status Public on Sep 09, 2016
Title Gene expression profiling of neutrophils and whole lung tissue from wildtype and Nrf2 null (Nfe2l2-/-) mice during S. pneumoniae pneumonia [whole lung]
Organism Mus musculus
Experiment type Expression profiling by array
Summary The transcription factor Nrf2 (gene symbol Nfe2l2) regulates the transcriptional response to oxidative stress and plays a critical protective role in the lungs.
These studies tested the role of Nrf2 during pneumonia induced by Streptococcus pneumoniae (SP) at 24 hours in mice and identified Nrf2-dependent genes and pathways in lung tissue and in recruited neutrophils.
 
Overall design Total RNA was isolated from whole lungs obtained from wildtype (WT) and Nrf2 null mice 24 hours after intratracheal instillation of Streptococcus pneumoniae (SP) or an equivalent volume of phosphate-buffered saline (PBS). Gene expression was profiled using Affymetrix Mouse Gene 2.1 ST arrays (Santa Clara, CA, USA).
 
Contributor(s) Gomez JC, Dang H, Doerschuk CM
Citation(s) 27566827
Submission date Jun 22, 2016
Last update date Nov 04, 2018
Contact name Claire M. Doerschuk
Organization name University of North Carolina at Chapel Hill
Department Marsico Lung Institute
Street address Marsico Hall 7205 CB#7248
City Chapel Hill
State/province NC
ZIP/Postal code 27599-7248
Country USA
 
Platforms (1)
GPL22070 [MoGene-2_1-st] Affymetrix Mouse Gene 2.1 ST Array [transcript-level na35ens81]
Samples (16)
GSM2210931 WT whole lung PBS rep1
GSM2210932 WT whole lung PBS rep2
GSM2210933 WT whole lung PBS rep3
This SubSeries is part of SuperSeries:
GSE83615 Gene expression profiling of neutrophils and whole lung tissue from wildtype and Nrf2 null (Nfe2l2-/-) mice during S. pneumoniae pneumonia
Relations
BioProject PRJNA326508

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83612_RAW.tar 81.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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