GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE83427 Query DataSets for GSE83427
Status Public on Jul 10, 2016
Title Assay for Transposase-Accessible Chromatin with high throughput sequencing (ATAC-Seq) reveals lncRNA MANTIS important for the angiogenic function of endothelial cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The angiogenic function of endothelial cells is tightly regulated but the impact of long non-coding RNAs (lncRNA) remains unclear. The lncRNA yielded to be an epigenetically restricted endothelial lncRNAs. Here, the chromatin accessibility after knockdown of MANTIS was investigated. It revealed changes on chromatin accessibility on several promoters which are known to be important for endothelial angiogenic function.
Overall design ATAC-seq profiles after knockdown with scrambled or MANTIS siRNA in human umbilical vein endothelial cells (HUVEC).
Contributor(s) Leisegang MS, Künne C, Günther S, Brandes RP
Citation(s) 28351900
Submission date Jun 16, 2016
Last update date May 15, 2019
Contact name Matthias S Leisegang
Organization name Goethe-University
Department Institute for Cardiovascular Physiology
Street address Theodor-Stern-Kai 7
City Frankfurt
ZIP/Postal code 60590
Country Germany
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (2)
GSM2202930 siSCR_ATAC_Seq
GSM2202931 siMTS_ATAC_Seq
BioProject PRJNA325880
SRA SRP076664

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83427_peaks.txt.gz 2.4 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap