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Series GSE83380 Query DataSets for GSE83380
Status Public on Sep 01, 2016
Title Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary ZFAT is a nuclear protein that harbors putative DNA-binding domains. Studies in mice have shown that ZFAT plays a critical role in survival and differentiation in T cells. However, molecular mechanisms whereby ZFAT regulates gene expression programs in T cells remain poorly unknown. We here identify the direct target genes of ZFAT in thymocytes through combination of chromatin immunoprecipitation with sequencing and transcriptional profiling.
Overall design ChIPseq data were obtained for a zinc-finger transcription factor, ZFAT, and histone modifications (H3K9me3 and H3K9ac/K27ac) to further elucidate the functions of ZFAT in thymocytes.
Contributor(s) Ishikura S, Tsunoda T, Nakabayashi K, Shirasawa S
Citation(s) 27591365
Submission date Jun 15, 2016
Last update date May 15, 2019
Contact name Kazuhiko Nakabayashi
Organization name National Research Institute for Child Health and Development
Department Department of Maternal-Fetal Biology
Street address 2-10-1 Okura
City Setagaya
State/province Tokyo
ZIP/Postal code 157-8535
Country Japan
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (12)
GSM2200440 Zfatf/f_thymocytes_ZFAT_ChIPseq
GSM2200441 Zfatf/f_thymocytes_input
GSM2200442 Zfatf/f-LckCre_thymocytes_ZFAT_ChIPseq
BioProject PRJNA325737
SRA SRP076595

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE83380_RAW.tar 500.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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