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Series GSE83306 Query DataSets for GSE83306
Status Public on Dec 31, 2017
Title Social status alters immune regulation and response to infection [PBMC_ATACseq]
Organism Macaca mulatta
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Social status is one of the strongest predictors of disease risk and mortality in humans, and often influences Darwinian fitness in social mammals more generally. To understand the biological basis of these effects, we combined a functional genomics approach with sequential social status manipulations in rhesus macaques to investigate how social status alters immune function. We demonstrate causal, but largely plastic, effects of social status on immune cell proportions, cell type-specific gene expression levels, and the gene expression and cytokine response to infection. Further, we identify specific transcription factor signaling pathways that explain these differences, particularly status-associated polarization of the TLR4 signaling pathway towards pro-inflammatory versus anti-viral responses. Our findings provide an unprecedented level of insight into the direct biological effects of social inequality on immune function, thus contributing to an improved understanding of social gradients in health and the evolution of social hierarchies.
For social status, please refer to table S1 in the manuscript.
Overall design ATAC-seq of PBMCs from 3 female rhesus macaques
Contributor(s) Snyder-Mackler N, Tung J
Citation(s) 27885030
Submission date Jun 13, 2016
Last update date May 15, 2019
Contact name Noah Snyder-Mackler
Phone 3025938430
Organization name Arizona State University
Lab Snyder-Mackler
Street address 427 East Tyler Mall
City Tempe
State/province AZ
ZIP/Postal code 85281
Country USA
Platforms (1)
GPL21120 Illumina NextSeq 500 (Macaca mulatta)
Samples (3)
GSM2199355 SGE_ATAC_114
GSM2199356 SGE_ATAC_124
GSM2199357 SGE_ATAC_130
This SubSeries is part of SuperSeries:
GSE83307 Social status alters immune regulation and response to infection
BioProject PRJNA325537
SRA SRP076489

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Supplementary file Size Download File type/resource
GSE83306_SGE_ATAC_macs2_summits.bed.gz 661.2 Kb (ftp)(http) BED
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Raw data are available in SRA
Processed data are available on Series record

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