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Series GSE81978 Query DataSets for GSE81978
Status Public on Feb 07, 2017
Title Effect of SF3B1 suppression in cancer cells with different SF3B1 copy-number levels
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Breast cancer cell lines containing stable dox inducible shRNAs targeting SF3B1 were profiled by RNA sequencing. We determined the effect of gene expression and splicing changes before and after knocking down SF3B1 in cell lines with normal copy number (SF3B1neutral) or partial copy loss (SF3B1loss) cell lines
Overall design RNA profiles for SF3B1 suppression were generated from 8 breast cancer cell line pairs (-/+ dox) with no techincal replicates.
Contributor(s) Paolella BR, Gibson WJ
Citation(s) 28177281
NIH grant(s)
Grant ID Grant title Affiliation Name
F30 CA192725 Hemizygous deletion of esential genes enables a novel therqpeutic vulnerability in cancer HARVARD UNIVERSITY (MEDICAL SCHOOL) Gibson
F32 CA180653 Cancer Specific Sensitivity to Suppression of Spliceosome Components DANA-FARBER CANCER INSTITUTE Paolella
L40 CA179861 Cancer-Specific Vulnerability to Suppression of Spliceosome Components: Neuroblastoma Specific Sensitivity to Spliceosome Inhibition LOAN REPAYMENT APPLICATIONS Paolella
Submission date May 27, 2016
Last update date May 15, 2019
Contact name Brenton Paolella
Organization name Dana-Farber Cancer Institute
Lab Rameen Beroukhim
Street address 450 Brookline Ave. Smith 1010
City Boston
State/province Massachusetts
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (16)
GSM2179001 Hs5sh4plus
GSM2179002 BT5sh4plus
GSM2179003 Hs5sh4minus
BioProject PRJNA323711
SRA SRP075880

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Supplementary file Size Download File type/resource
GSE81978_Gene_level_SF3B1_suppression.rpkm.gct.gz 2.7 Mb (ftp)(http) GCT
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