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Series GSE81969 Query DataSets for GSE81969
Status Public on May 27, 2016
Title Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although abundance of H4K20me3 increases during cellular senescence. Cellular senescence is a stable proliferation arrest and tumor suppressor process, triggered by diverse molecular cues, including activated oncogenes. Here, we set out to better understand the function of H4K20me3 in senescence and tumor suppression.
Overall design ChIP-seq of H4K20me3 in RAS induced senescence and associated controls in IMR90 cells was performed. In total, four samples are included in the dataset which associates with a dataset that includes H4K20me3 ChIP in proliferating (PD32) and replicative senescent (PD87) samples.
Contributor(s) Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Adams PD
Citation(s) 27457071
Submission date May 27, 2016
Last update date Apr 02, 2020
Contact name Peter Adams
Organization name University of Glasgow, Beatson Institute for Cancer Research
Street address Switchback Rd, Bearsden
City Glasgow
ZIP/Postal code G61 1BD
Country United Kingdom
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (8)
GSM2178852 Control1 H4K20me3 ChIP-seq
GSM2178853 Control2 H4K20me3 ChIP-seq
GSM2178854 RAS1 H4K20me3 ChIP-seq
BioProject PRJNA323528
SRA SRP075797

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Supplementary file Size Download File type/resource
GSE81969_CON_H4K20me3_vs_H4_Rep1_FDR01.bed.gz 4.0 Kb (ftp)(http) BED
GSE81969_CON_H4K20me3_vs_H4_Rep2_FDR01.bed.gz 17.8 Kb (ftp)(http) BED
GSE81969_RAS_H4K20me3_vs_H4_Rep1_FDR01.bed.gz 90.5 Kb (ftp)(http) BED
GSE81969_RAS_H4K20me3_vs_H4_Rep2_FDR01.bed.gz 86.6 Kb (ftp)(http) BED
GSE81969_RAS_vs_CON_H4K20me3_Diffbind.bed.gz 85.6 Kb (ftp)(http) BED
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