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Series GSE81911 Query DataSets for GSE81911
Status Public on Aug 18, 2017
Title ChIP-sequencing of histone marks in WT and Fmr1-/- (KO) neurons and mice
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Widespread misregulation of histone modifcations occur in FXS, most notably increases in marks associated with active transcription.
Overall design 7DIV cultured cortical neurons from WT or Fmr1 KO mice were processed for H3K4me3 and H3K27ac ChIP. In addition, neurons sorted from cerebellar tissue from WT and Fmr1 KO BAC-TRAP NeuroD1 P15 mice were used for H3K4me3 ChIP, performed in triplicate
Contributor(s) Korb E
Citation(s) 28823556
NIH grant(s)
Grant ID Grant title Affiliation Name
K99 MH111836 The histone code of neuronal function and dysfunction THE ROCKEFELLER UNIVERSITY Erica Megan Korb
Submission date May 25, 2016
Last update date Jul 25, 2021
Contact name Erica Korb
Organization name University of Pennsylvania
Lab Korb Lab
Street address 3400 Civic Center Boulevard
City Philadelphia
State/province PENNSYLVANIA
ZIP/Postal code 19104
Country USA
Platforms (2)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (30)
GSM2177669 H3K4me3_neurons_WT_input fvb
GSM2177670 H3K4me3_neurons_WT_IP fvb
GSM2177671 H3K4me3_neurons_KO_input fvb
This SubSeries is part of SuperSeries:
GSE81912 Fragile X Syndrome causes epigenetic disruptions treatable with BET inhibitor Jq1
BioProject PRJNA323399
SRA SRP075729

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE81911_RAW.tar 7.2 Gb (http)(custom) TAR (of TDF)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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