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| Status |
Public on Aug 18, 2017 |
| Title |
ChIP-sequencing of histone marks in WT and Fmr1-/- (KO) neurons and mice |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Widespread misregulation of histone modifcations occur in FXS, most notably increases in marks associated with active transcription.
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| Overall design |
7DIV cultured cortical neurons from WT or Fmr1 KO mice were processed for H3K4me3 and H3K27ac ChIP. In addition, neurons sorted from cerebellar tissue from WT and Fmr1 KO BAC-TRAP NeuroD1 P15 mice were used for H3K4me3 ChIP, performed in triplicate
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| Contributor(s) |
Korb E |
| Citation(s) |
28823556 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| K99 MH111836 |
The histone code of neuronal function and dysfunction |
THE ROCKEFELLER UNIVERSITY |
Erica Megan Korb |
|
| |
| Submission date |
May 25, 2016 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Erica Korb |
| Organization name |
University of Pennsylvania
|
| Lab |
Korb Lab
|
| Street address |
3400 Civic Center Boulevard
|
| City |
Philadelphia |
| State/province |
PENNSYLVANIA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (30)
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| This SubSeries is part of SuperSeries: |
| GSE81912 |
Fragile X Syndrome causes epigenetic disruptions treatable with BET inhibitor Jq1 |
|
| Relations |
| BioProject |
PRJNA323399 |
| SRA |
SRP075729 |
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