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Series GSE81800 Query DataSets for GSE81800
Status Public on May 24, 2016
Title Effects of blocking IL-17A on lung gene expression after ozone exposure in obese (db/db) mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Obese mice have an augmented response to Ozone exposure (2 ppm for 3 hours and studied 24 hours later), including increase airway hyperresponsiveness and BAL inflammation when compared to WT ozone exposed mice. When IL-17A is block with systemic injected of IL-17A antibodies there is a decrease of response in the obese mice. To determine the mechanism of action, RNA was extracted from the lungs of IL-17A and Isotype injected ozone exposed obese mice and microarray analysis of gene expression was performed.
Overall design Lungs were harvested from db/db mice exposed to air and ozone and injected with anti-IL-17A and isotype.
Contributor(s) Shore SA, Mathews JA, Kasahara DI
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Submission date May 23, 2016
Last update date Apr 18, 2017
Contact name Stephanie A Shore
Organization name Harvard School of Public Health
Department Environmental Health
Lab Shore Lab
Street address 665 Huntigton Av Bld1 room 307
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (12)
GSM2175635 db_IL17_ozone_1
GSM2175636 db_IL17_ozone_2
GSM2175637 db_IL17_ozone_4
BioProject PRJNA322558

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE81800_RAW.tar 52.9 Mb (http)(custom) TAR (of CEL)
GSE81800_normalized_data_with_statistics.txt.gz 3.6 Mb (ftp)(http) TXT
Processed data included within Sample table
Processed data are available on Series record

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