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Series GSE81603 Query DataSets for GSE81603
Status Public on May 20, 2016
Title Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD14+ cells, exon level]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We analyzed the gene expression patterns of different blood cell types before and during fingolimod treatment in a group of patients with relapsing-remitting multiple sclerosis (RRMS).
Affymetrix Human Transcriptome Arrays (HTA) 2.0 were used to obtain gene expression profiles of immune cell populations from 10 RRMS patients within the first 3 months of fingolimod treatment.
This GEO entry provides the Affymetrix HTA 2.0 microarray data of peripheral blood CD14+ cells, preprocessed according to the exon level workflow.
Overall design EDTA blood samples were taken from all patients immediately before first and second fingolimod administration as well as after 3 months of therapy.
Total RNA of CD14+ cells positively selected from each blood sample was extracted, labeled and hybridized to high-density Affymetrix HTA 2.0 microarrays to quantify the transcript levels.
Contributor(s) Hecker M, Koczan D, Zettl UK
Citation(s) 29314605, 30040082
Submission date May 18, 2016
Last update date Jul 26, 2018
Contact name Michael Hecker
Organization name University of Rostock
Department Department of Neurology
Lab Division of Neuroimmunology
Street address Gehlsheimer Str. 20
City Rostock
ZIP/Postal code 18147
Country Germany
Platforms (1)
GPL17585 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [probe set (exon) version]
Samples (30)
GSM2157839 Patient 1, CD14+ cells, before first dose of fingolimod [exon-level]
GSM2157840 Patient 1, CD14+ cells, before second dose of fingolimod [exon-level]
GSM2157841 Patient 1, CD14+ cells, after 3 months of fingolimod treatment [exon-level]
This SubSeries is part of SuperSeries:
GSE73174 Transcriptome data of multiple sclerosis patients receiving fingolimod therapy
BioProject PRJNA322151

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Supplementary file Size Download File type/resource
GSE81603_RAW.tar 925.0 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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