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Series GSE81255 Query DataSets for GSE81255
Status Public on May 10, 2016
Title Nfib promotes Metastasis through a Widespread Increase in Chromatin Accessibility [ATAC-seq]
Organisms Homo sapiens; Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We describe Nfib as an important regulator of chromatin accessibility in Small cell lung cancer (SCLC).
Overall design ATAC seq was performed on [1] ex vivo samples from primary tumors and metastases of a mouse model for SCLC (4 samples of each plus technical replicates of 7 samples for a total of 15 samples)
[2] cell lines derived from mouse models for SCLC.
[3] Nfib loss of function in murine SCLC cell lines (shLuc are controls, sh2 is shRNA that knocks down Nfib)
[4] Nfib gain of function in murine SCLC cell lines and human SCLC lines (empty indicates control cells, Nfib indicates cells overexpressing Nfib)
Contributor(s) Denny S, Yang D, Sage J, Greenleaf W, Winslow M
Citation(s) 27374332
Submission date May 09, 2016
Last update date May 15, 2019
Contact name William Greenleaf
Organization name Stanford University
Street address 279 Campus Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
Platforms (3)
GPL16417 Illumina MiSeq (Mus musculus)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (67)
GSM2147562 L1-A [ATAC-seq]
GSM2147563 L1-B [ATAC-seq]
GSM2147564 L2-A [ATAC-seq]
This SubSeries is part of SuperSeries:
GSE81258 Nfib promotes Metastasis through a Widespread Increase in Chromatin Accessibility
BioProject PRJNA321073
SRA SRP074733

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource 402.6 Mb (ftp)(http) BW 413.0 Mb (ftp)(http) BW 303.9 Mb (ftp)(http) BW 268.3 Mb (ftp)(http) BW 389.4 Mb (ftp)(http) BW 327.5 Mb (ftp)(http) BW 373.1 Mb (ftp)(http) BW 409.4 Mb (ftp)(http) BW 306.9 Mb (ftp)(http) BW 360.7 Mb (ftp)(http) BW 405.8 Mb (ftp)(http) BW 386.4 Mb (ftp)(http) BW
GSE81255_all_merged.H14_H29_H52_H69_H82_H88_peaks.broadPeak.gz 4.9 Mb (ftp)(http) BROADPEAK
GSE81255_cell_lines.deseq_results.csv.gz 32.2 Mb (ftp)(http) CSV
GSE81255_cell_mod.deseq_results.csv.gz 23.3 Mb (ftp)(http) CSV
GSE81255_human_oe.deseq_results.csv.gz 3.7 Mb (ftp)(http) CSV 470.0 Mb (ftp)(http) BW 473.8 Mb (ftp)(http) BW
GSE81255_peak_calls_mm9.nheader.up.bed.gz 242.6 Kb (ftp)(http) BED
GSE81255_primary_tissue.deseq_results.csv.gz 43.9 Mb (ftp)(http) CSV
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