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Series GSE80722 Query DataSets for GSE80722
Status Public on Jun 06, 2016
Title Transcriptome analysis of patient-derived xenograft models of HER2+ breast cancer brain metastases
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To gain insights into tumor heterogeneity in anti-cancer drug responses of patient-derived xenograft models of HER2+ breast cancer brain metastases, we performed transcriptome gene expression profiling by Ion AmpliSeqâ„¢ Transcriptome sequencing that targets more than 20,000 human genes. Our data found that all anti-cancer drugs responders have significantly higher expression levels of AKT-mTOR-dependent signature genes as compared to the non-responders, suggesting that most HER2+ breast cancer brain metastases are depend on the AKT-mTOR pathway
Overall design Gene expression profiles of five PDX samples were generated by Ion AmpliSeq Transcriptome sequencing, in duplcate, using Ion torrent Proton machine.
Contributor(s) Zhao J, Ni J, Xie S
Citation(s) 27270588
Submission date Apr 27, 2016
Last update date May 15, 2019
Contact name Jean Zhao
Organization name Dana Farber Cancer Institute
Department Cancer Biology
Lab Jean Zhao
Street address 450 Brookline Ave, SM936
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (10)
GSM2134295 PDX_TX_DFBM354_rep1
GSM2134296 PDX_TX_DFBM355_rep1
GSM2134297 PDX_TX_DFBM463_rep1
BioProject PRJNA319811
SRA SRP074069

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Supplementary file Size Download File type/resource
GSE80722_P1_rep1.bcmatrix.xls.gz 675.2 Kb (ftp)(http) XLS
GSE80722_P1_rep2.bcmatrix.xls.gz 673.5 Kb (ftp)(http) XLS
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Raw data are available in SRA

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