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| Status |
Public on Dec 04, 2007 |
| Title |
Expression analyses of glioblastoma derived neurosphere cultures |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes.
Microarray analysis showed that the 4 GSf cell lines shared expression profiles dominated by genes involved in nervous system development and neuropeptide signaling, while the 5 GSr lines shared expression signatures enriched for extracellular matrix-proteins.
Keywords: Cell line comparison
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| Overall design |
Affymetrix HG-U133 Plus 2.0 chips were employed for expression profiling from 9 different glioblastoma derived neurosphere cultures in two biological replicates.
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| Contributor(s) |
Günther HS, Schmidt N, Phillips HS, Kemming D, Kharbanda S, Soriano R, Modrusan Z, Meissner H, Westphal M, Lamszus K |
| Citation(s) |
18037961 |
| Submission date |
Jun 07, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Hauke Simon Guenther |
| Organization name |
UKE
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| Department |
Neurochirurgie
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| Lab |
Endolab2
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| Street address |
Martinistraße 52
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| City |
Hamburg |
| ZIP/Postal code |
20246 |
| Country |
Germany |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (17)
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| Relations |
| BioProject |
PRJNA100875 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8049_RAW.tar |
142.0 Mb |
(http)(custom) |
TAR (of CEL, EXP) |
| Processed data included within Sample table |
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