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Series GSE80434 Query DataSets for GSE80434
Status Public on Aug 23, 2016
Title Molecular Signatures Associated with ZIKV Exposure in Human Cortical Neural Progenitors
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function remains elusive. Here we systematically profiled transcriptomes of human neural progenitor cells (hNPCs) exposed to Asian ZIKVC, African ZIKVM, and Dengue virus (DENV). DENV causes distinct gene expression changes; and ZIKV has a broader impact on the expression of gene involved in DNA replication and repair. While overall expression profiles are similar, ZIKVC, but not ZIKVM, induces upregulation of viral response genes. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. Further investigation of ZIKV-host interactions based our transcriptomic datasets may help to illuminate neural virulence determinants of ZIKV in patients.
Overall design Gene Expression Analyses of the cells infected with different flaviviruses
Contributor(s) Jin P
Citation(s) 27580721
Submission date Apr 19, 2016
Last update date May 15, 2019
Contact name Peng Jin
Phone 4047273729
Organization name Emory University
Department Human Genetics
Lab Jin Lab
Street address 615 Michael St., Rm 325
City Atlanta
State/province Georgia
ZIP/Postal code 30322
Country USA
Platforms (3)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
GPL15520 Illumina MiSeq (Homo sapiens)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (16)
GSM2127237 RNAseq-NPC-DENV-1
GSM2127238 RNAseq-NPC-DENV-2
GSM2127239 RNAseq-NPC-DENV-3
BioProject PRJNA318898
SRA SRP073493

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE80434_RAW.tar 12.9 Mb (http)(custom) TAR (of FPKM_TRACKING)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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