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Series GSE80239 Query DataSets for GSE80239
Status Public on Sep 01, 2017
Title EZH2 inhibitor-mediated transcriptional profiling in prostate cancer cells [RNA-seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We reported here the gene expression profiles that were mediated upon the treatment of EZH2 inhibitor in two hormone-refractory prostate cancer cell lines: the sensitive, AR-positive abl cells and the insensitive, AR-null DU145 cells.
Overall design We treated both types of prostate cancer cells with two different EZH2 inhibitors (GSK126 or EPZ-6438) at final concentrations of 5 uM for 60-72 hrs, and then collected RNAs for gene expression profiling.
Contributor(s) Xu K, Chen C
Citation(s) 35031563
Submission date Apr 13, 2016
Last update date Feb 08, 2022
Contact name Kexin Xu
Organization name UT Health Science Center at San Antonio
Department Molecular Medicine
Street address 7703 Floyd Curl, MC 8257
City San Antonio
State/province TX
ZIP/Postal code 78229
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (12)
GSM2122582 RNASeq_abl_DMSO duplicate 1
GSM2122583 RNASeq_abl_DMSO duplicate 2
GSM2122584 RNASeq_abl_EPZ duplicate 1
This SubSeries is part of SuperSeries:
GSE80240 Distinct changes in transcriptional profiles and epigenetic patterns mediated by EZH2 inhibitors in sensitive and insensitive prostate cancer cells
BioProject PRJNA318380
SRA SRP073247

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Supplementary file Size Download File type/resource
GSE80239_DU145_EPZ_counts_DE.txt.gz 902.5 Kb (ftp)(http) TXT
GSE80239_DU145_GSK_counts_DE.txt.gz 903.0 Kb (ftp)(http) TXT
GSE80239_abl_EPZ_counts_DE.txt.gz 875.2 Kb (ftp)(http) TXT
GSE80239_abl_GSK_counts_DE.txt.gz 819.7 Kb (ftp)(http) TXT
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