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Series GSE79791 Query DataSets for GSE79791
Status Public on Jun 09, 2017
Title BMP (Bone morphogenetic protein) signaling network regulates mesenchymal stem cell lineage commitment during tooth development
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Mesenchymal stem cells (MSCs) are multipotent progenitor cells present in various mesenchymal tissues that undergo strict lineage-specific differentiation programs, faithful to their unique tissue origins. However, the key regulators that activate dental pulp MSC commitment to odontogenesis remain unclear. In this study, we utilized an inducible Cre/loxP system to interrupt BMP signaling in apical MSCs at the onset of molar root formation in order to investigate the functional requirement for BMP signaling and its downstream targets in MSC cell fate determination during tooth morphogenesis.
Overall design mRNA profiling of MSC to study role of BMP signaling in tooth morphogenesis
Contributor(s) Feng J, Jing J, Li J, Z H, Punj V, Zhang T, T X, Chai Y
Citation(s) 28576771
Submission date Mar 31, 2016
Last update date May 15, 2019
Contact name Vasu Punj
Organization name USC
Street address Biggy Street
City Los Angeles
State/province CA
ZIP/Postal code 90033
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM2102841 JF-8
GSM2102842 JF-9
GSM2102843 JF-11
BioProject PRJNA316997
SRA SRP072697

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Supplementary file Size Download File type/resource
GSE79791_File_1_normalized_RPKM_values_Vasu_J_Chai_.txt.gz 496.5 Kb (ftp)(http) TXT
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