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Series GSE79600 Query DataSets for GSE79600
Status Public on May 18, 2016
Title Memory CD8+ T cells require stress-levels of acetate for optimal function
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary How systemic metabolic alterations during acute infections impact immune-cell function remains poorly understood. Hess and colleagues demonstrate that acetate rapidly increases during infections, which drives acetylation of GAPDH in memory CD8+ T cells and thereby catalyzes the rapid recall response.
Overall design Comparison of mRNA profile of control vs. 3d acetate exposed memory OT-I T cells
Contributor(s) Balmer ML, Ma EH, Bantug GR, Grählert J, Pfister S, Glatter T, Jauch A, Dimeloe S, Slack E, Dehio P, Krzyzaniak MA, King CG, Burgener A, Fischer M, Develioglu L, Belle R, Recher M, Bonilla WV, Pinschewer DD, Macpherson AJ, Hapfelmeier S, Jones RG, Hess C
Citation(s) 27212436
Submission date Mar 25, 2016
Last update date May 15, 2019
Contact name Christoph Hess
Organization name University Basel
Department Department of Biomedicine
Lab Immunobiology
Street address Hebelstrasse 20
City Basel
ZIP/Postal code 4031
Country Switzerland
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM2098926 Control 1
GSM2098927 Acetate 2
GSM2098928 Control 3
BioProject PRJNA316377
SRA SRP072343

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE79600_RAW.tar 610.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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