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Series GSE78996 Query DataSets for GSE78996
Status Public on Jul 01, 2016
Title Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis ABH Mouse Model by RNA Sequencing
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary RNA sequencing was used to explore global gene expression in the chronic relapsing and secondary progressive EAE (pEAE) Biozzi ABH mouse model of MS. Spinal cord tissue RNA from pEAE Biozzi ABH mice and healthy littermate controls was sequenced. 2,072 genes were differentially expressed (q<0.05) from which 1,397 were significantly upregulated and 675 were significantly downregulated. This hypothesis-free investigation characterised the genomic changes that describe the pEAE mouse model.
Overall design Examination of 3 control and 3 pEAE mice
Contributor(s) Sevastou I, Pryce G, Baker D, Selwood DL
Citation(s) 27355629
Submission date Mar 08, 2016
Last update date May 15, 2019
Contact name Ioanna Sevastou
Organization name UCL
Department Translational Research Office
Street address 149 Tottenham Court Road
City London
ZIP/Postal code W1T 7DN
Country United Kingdom
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (6)
GSM2083315 WT rep1
GSM2083316 WT rep2
GSM2083317 WT rep3
BioProject PRJNA314610
SRA SRP071304

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Supplementary file Size Download File type/resource
GSE78996_CTR_vs_EAE_Cuffdiff_analysis.xlsx 2.3 Mb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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