|
| Status |
Public on Jul 01, 2016 |
| Title |
Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis ABH Mouse Model by RNA Sequencing |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequencing was used to explore global gene expression in the chronic relapsing and secondary progressive EAE (pEAE) Biozzi ABH mouse model of MS. Spinal cord tissue RNA from pEAE Biozzi ABH mice and healthy littermate controls was sequenced. 2,072 genes were differentially expressed (q<0.05) from which 1,397 were significantly upregulated and 675 were significantly downregulated. This hypothesis-free investigation characterised the genomic changes that describe the pEAE mouse model.
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| |
|
| Overall design |
Examination of 3 control and 3 pEAE mice
|
| |
|
| Contributor(s) |
Sevastou I, Pryce G, Baker D, Selwood DL |
| Citation(s) |
27355629 |
| |
| Submission date |
Mar 08, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Ioanna Sevastou |
| E-mail(s) |
i.sevastou@ucl.ac.uk
|
| Organization name |
UCL
|
| Department |
Translational Research Office
|
| Street address |
149 Tottenham Court Road
|
| City |
London |
| ZIP/Postal code |
W1T 7DN |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA314610 |
| SRA |
SRP071304 |
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