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Series GSE78873 Query DataSets for GSE78873
Status Public on May 08, 2016
Title A long noncoding RNA lincRNA-EPS acts as a transcriptional brake to restrain inflammation
Organism Mus musculus
Experiment type Other
Summary LincRNA-EPS is a long noncoding RNA that is expressed in macrophages and downregulated upon exposure to diverse microbial products. Analysis of macrophages from lincRNA-EPS-deficient mice revealed a specific role for this lincRNA in restraining immune response gene (IRG) expression. Mechanistically, lincRNA-EPS associates with chromatin at regulatory regions of IRGs to repress their transcription. To gain insight into the molecular function of lincRNA-EPS on chromatin, we generated ATAC-Seq libraries from wildtype and lincRNA-EPS-deficient macrophages stimulated with LPS.
Overall design We examined chromatin structure using ATAC-seq in wild-type and lincRNA-EPS knock-out macrophages stimulated with LPS
Contributor(s) Atianand M, Shen Y, Satpathy A, Chang H, Fitzgerald K
Citation(s) 27315481
Submission date Mar 03, 2016
Last update date May 15, 2019
Contact name Howard Chang
Organization name Stanford University
Street address 269 Campus Dr. Stanford, CA
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (12)
GSM2080017 WT Macrophage 0HR Rep1
GSM2080018 WT Macrophage 0HR Rep2
GSM2080019 WT Macrophage 2HR Rep1
BioProject PRJNA314247
SRA SRP071137

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Supplementary file Size Download File type/resource
GSE78873_RAW.tar 23.5 Mb (http)(custom) TAR (of NARROWPEAK)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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