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Series GSE78790 Query DataSets for GSE78790
Status Public on Mar 01, 2016
Title Transcriptome profiling in knock-in mouse models of Huntington's disease [Cerebellum_miRNA]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 6 and 10 months old knock-in mice with CAG lengths of 20, 50, 92, 140 along with littermate control wild-type animals
 
Overall design miRNA expression profiles were obtained via RNA-seq analysis performed on samples from the Cerebellum tissue of 6 and 10 months old knock-in mice with CAG lengths of 20, 50, 92, 140 along with littermate control wild-type animals.
 
Contributor(s) Aaronson J, Rosinski J
Citation(s) 29324753
Submission date Mar 01, 2016
Last update date May 15, 2019
Contact name Jeff Aaronson
E-mail(s) jeff.aaronson@chdifoundation.org
Phone (609) 945-9616
Organization name CHDI
Department Discovery & Systems Biology
Street address 155 Village Boulevard, Suite 200
City Princeton
State/province New Jersey
ZIP/Postal code 08540
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (96)
GSM2076822 Het (Q140) 10 months Female Cerebellum miRNA rep1
GSM2076823 Het (Q140) 10 months Female Cerebellum miRNA rep2
GSM2076824 Het (Q140) 10 months Female Cerebellum miRNA rep3
Relations
BioProject PRJNA313916
SRA SRP071005

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Supplementary file Size Download File type/resource
GSE78790_Cerebellum_FPKM.xlsx 829.3 Kb (ftp)(http) XLSX
GSE78790_Cerebellum_counts.xlsx 569.4 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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