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Series GSE78272 Query DataSets for GSE78272
Status Public on Feb 24, 2016
Title Transcriptome profiling in knock-in mouse models of Huntington's disease (cortex_mRNA).
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 6 and 10 month old knock-in mice with CAG lengths of 20, 50, 92, 140 along with littermate control wild-type animals
 
Overall design mRNA expression profiles were obtained via RNA-seq analysis performed on samples from the Cerebral Cortex tissue of 6 and 10 month old knock-in mice with CAG lengths of 20, 50, 92, 140 along with littermate control wild-type animals.
 
Contributor(s) Aaronson J, Rosinski J
Citation(s) 26900923
Submission date Feb 24, 2016
Last update date May 15, 2019
Contact name Jeff Aaronson
E-mail(s) jeff.aaronson@chdifoundation.org
Phone (609) 945-9616
Organization name CHDI
Department Discovery & Systems Biology
Street address 155 Village Boulevard, Suite 200
City Princeton
State/province New Jersey
ZIP/Postal code 08540
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (95)
GSM2070760 Het (Q140) 6 months Female Cortex mRNA rep1 398760_63648_1_L3.D705
GSM2070761 Het (Q140) 6 months Female Cortex mRNA rep2 398772_63724_1_L30
GSM2070762 Het (Q140) 6 months Female Cortex mRNA rep3 398776_63496_1_L6.D709
Relations
BioProject PRJNA313070
SRA SRP070769

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE78272_allelicSeires_q50Extension_FPKM_Brain_Cortex.xlsx 23.4 Mb (ftp)(http) XLSX
GSE78272_allelicSeires_q50Extension_counts_Brain_Cortex.xlsx 19.8 Mb (ftp)(http) XLSX
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Processed data are available on Series record
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