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Series GSE77972 Query DataSets for GSE77972
Status Public on Mar 01, 2016
Title Expression data from adult mouse Prefrontal Cortex following prenatal infection
Organism Mus musculus
Experiment type Expression profiling by array
Summary Prenatal exposure to infectious or inflammatory insults can increase the risk of neuropsychiatric disorders with neurodevelopmental components, including schizophrenia and autism. The molecular processes underlying this pathological association are only partially understood. Here, we implemented an unbiased genome-wide transcriptional profiling of the prefrontal cortex of mice exposed to prenatal infection on GD17 compared to control subjects in order to elucidate the long term molecular signature of late prenatal infection.
We used microarray analysis to investigate the long lasting gene expression changes in a well-established mouse model that is based on maternal treatment with the viral mimic poly(I:C) during pregnancy
Overall design C57BL/6 mice were treated with the synthetic viral mimetic poly(I:C) (5 mg/kg, i.v.) or control (saline, i.v.) solution on gestation day 17. Offspring were subjected to cognitive and behavioral testing in adulthood, and then whole genome gene expression analysis with Affymetrix Microarray and subsequent q-PCR validation were performed on the prefrontal Cortex.
Contributor(s) Richetto J, Meyer U, Riva MA, Cattaneo A
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Submission date Feb 16, 2016
Last update date Apr 18, 2017
Contact name Juliet Richetto
Organization name University of Zurich - Vetsuisse
Department Institute for Pharmacology and Toxicology
Street address Winterthurerstrasse 260
City Zurich
ZIP/Postal code 8057
Country Switzerland
Platforms (1)
GPL11533 [MoGene-1_1-st] Affymetrix Mouse Gene 1.1 ST Array [transcript (gene) version]
Samples (12)
GSM2063018 PFC control offspring, biological replicate 1
GSM2063019 PFC control offspring, biological replicate 2
GSM2063020 PFC control offspring, biological replicate 3
This SubSeries is part of SuperSeries:
GSE77973 Expression data from adult mouse brain regions following prenatal infection
BioProject PRJNA312229

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Supplementary file Size Download File type/resource
GSE77972_RAW.tar 52.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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