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| Status |
Public on Aug 11, 2017 |
| Title |
Expression data from an outbred model for type 2 diabetes development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To study the development mechanisms of type 2 diabetes, we examined multi-tissues' expression profiles of outbred mice fed with a high-fat diet (HFD) or regular chow at week 1, 9, and 18 and performed a novel dual eigen-analysis.
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| Overall design |
We initiated a project on the development process of T2D using a mouse model. Unlike the knockout approach commonly seen in other literatures, we took an outbred model to mimick the natural human population. The mice of 5-week-old were fed with regular chow (RC) or a high fat diet (HFD). At week 1, week 9 and week 18, we collected tissue samples from both diet groups and measured their mRNA abundances of the adipose, the liver and the pancreas respectively using the Affymetrix Mouse430-2.0 Array.
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| Contributor(s) |
Li L, Wang Y |
| Citation(s) |
28698587 |
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| Submission date |
Feb 16, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Lei Li |
| E-mail(s) |
lilei@amss.ac.cn
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| Organization name |
Academy of Mathematics and Systems Science
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| Street address |
No. 55 Zhongguancun East Road, 100190
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| City |
Beijing |
| ZIP/Postal code |
100190 |
| Country |
China |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (62)
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| GSM2061955 |
mouse label 10, diet HFD, tissue adipose, time/age Week 9 |
| GSM2061958 |
mouse label 10, diet HFD, tissue liver, time/age Week 9 |
| GSM2061960 |
mouse label 10, diet HFD, tissue pancreas, time/age Week 9 |
| GSM2061962 |
mouse label 35, diet HFD, tissue adipose, time/age Week 9 |
| GSM2061964 |
mouse label 35, diet HFD, tissue liver, time/age Week 9 |
| GSM2061966 |
mouse label 35, diet HFD, tissue pancreas, time/age Week 9 |
| GSM2061967 |
mouse label 36, diet HFD, tissue adipose, time/age Week 1 |
| GSM2061969 |
mouse label 36, diet HFD, tissue liver, time/age Week 1 |
| GSM2061971 |
mouse label 38, diet HFD, tissue adipose, time/age Week 1 |
| GSM2061972 |
mouse label 38, diet HFD, tissue liver, time/age Week 1 |
| GSM2061974 |
mouse label 38, diet HFD, tissue pancreas, time/age Week 1 |
| GSM2061976 |
mouse label 40, diet HFD, tissue adipose, time/age Week 1 |
| GSM2061977 |
mouse label 40, diet HFD, tissue liver, time/age Week 1 |
| GSM2061979 |
mouse label 40, diet HFD, tissue pancreas, time/age Week 1 |
| GSM2061981 |
mouse label 7, diet HFD, tissue adipose, time/age Week 9 |
| GSM2061982 |
mouse label 7, diet HFD, tissue liver, time/age Week 9 |
| GSM2061984 |
mouse label 7, diet HFD, tissue pancreas, time/age Week 9 |
| GSM2061986 |
mouse label 19, diet RC, tissue adipose, time/age Week 1 |
| GSM2061987 |
mouse label 19, diet RC, tissue liver, time/age Week 1 |
| GSM2061989 |
mouse label 19, diet RC, tissue pancreas, time/age Week 1 |
| GSM2061991 |
mouse label 1, diet RC, tissue adipose, time/age Week 9 |
| GSM2061993 |
mouse label 1, diet RC, tissue liver, time/age Week 9 |
| GSM2061994 |
mouse label 1, diet RC, tissue pancreas, time/age Week 9 |
| GSM2061996 |
mouse label 20, diet RC, tissue adipose, time/age Week 1 |
| GSM2061998 |
mouse label 20, diet RC, tissue liver, time/age Week 1 |
| GSM2061999 |
mouse label 20, diet RC, tissue pancreas, time/age Week 1 |
| GSM2062001 |
mouse label 21, diet RC, tissue adipose, time/age Week 1 |
| GSM2062003 |
mouse label 21, diet RC, tissue liver, time/age Week 1 |
| GSM2062004 |
mouse label 21, diet RC, tissue pancreas, time/age Week 1 |
| GSM2062006 |
mouse label 5, diet RC, tissue liver, time/age Week 9 |
| GSM2062008 |
mouse label 5, diet RC, tissue pancreas, time/age Week 9 |
| GSM2062009 |
mouse label 5, diet RC, tissue adipose, time/age Week 9 |
| GSM2062011 |
mouse label 17, diet HFD, tissue adipose, time/age Week 18 |
| GSM2062013 |
mouse label 17, diet HFD, tissue liver, time/age Week 18 |
| GSM2062014 |
mouse label 17, diet HFD, tissue pancreas, time/age Week 18 |
| GSM2062016 |
mouse label 11, diet HFD, tissue adipose, time/age Week 18 |
| GSM2062018 |
mouse label 11, diet HFD, tissue liver, time/age Week 18 |
| GSM2062020 |
mouse label 1, diet HFD, tissue pancreas, time/age Week 18 |
| GSM2062021 |
mouse label 26, diet HFD, tissue adipose, time/age Week 18 |
| GSM2062023 |
mouse label 26, diet HFD, tissue liver, time/age Week 18 |
| GSM2062025 |
mouse label 26, diet HFD, tissue pancreas, time/age Week 18 |
| GSM2062027 |
mouse label 2, diet HFD, tissue adipose, time/age Week 18 |
| GSM2062028 |
mouse label 2, diet HFD, tissue liver, time/age Week 18 |
| GSM2062030 |
mouse label 2, diet HFD, tissue pancreas, time/age Week 18 |
| GSM2062032 |
mouse label 4, diet HFD, tissue adipose, time/age Week 18 |
| GSM2062034 |
mouse label 4, diet HFD, tissue liver, time/age Week 18 |
| GSM2062036 |
mouse label 4, diet HFD, tissue pancreas, time/age Week 18 |
| GSM2062037 |
mouse label 11, diet RC, tissue adipose, time/age Week 18 |
| GSM2062039 |
mouse label 11, diet RC, tissue liver, time/age Week 18 |
| GSM2062041 |
mouse label 11, diet RC, tissue pancreas, time/age Week 18 |
| GSM2062042 |
mouse label 17, diet RC, tissue adipose, time/age Week 9 |
| GSM2062044 |
mouse label 17, diet RC, tissue liver, time/age Week 9 |
| GSM2062046 |
mouse label 17, diet RC, tissue pancreas, time/age Week 9 |
| GSM2062047 |
mouse label 7, diet RC, tissue adipose, time/age Week 18 |
| GSM2062049 |
mouse label 7, diet RC, tissue liver, time/age Week 18 |
| GSM2062051 |
mouse label 7, diet RC, tissue pancreas, time/age Week 18 |
| GSM2062052 |
mouse label 9, diet RC, tissue adipose, time/age Week 18 |
| GSM2062054 |
mouse label 9, diet RC, tissue liver, time/age Week 18 |
| GSM2062056 |
mouse label 9, diet RC, tissue pancreas, time/age Week 18 |
| GSM2062058 |
mouse label 12, diet HFD, tissue adipose, time/age Week 18 |
| GSM2062059 |
mouse label 12, diet HFD, tissue liver, time/age Week 18 |
| GSM2062061 |
mouse label 12, diet HFD, tissue pancreas, time/age Week 18 |
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| Relations |
| BioProject |
PRJNA312178 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE77943_RAW.tar |
201.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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