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Series GSE76927 Query DataSets for GSE76927
Status Public on Mar 30, 2016
Title ChIP-seq analysis of E2f4, H3K4me2 and H3K27ac in the mouse livers
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Arid1a is the subunit of SWI/SNF complex, which was reported to guide SWI/SNF to DNA. Here, we found that loss of Arid1a in the liver results in improved liver regeneration after partial hepatectomy.Genome-wide analysis showed that after hepatectomy,loss of Arid1a reduces the recruitment and activity of E2F4 on target promoters, resulting in expression programs that favor regeneration during injury. Correspondingly, these promoters showed increased H3k4me2 and H3k27ac marks, indicating de-repression of these E2f target genes.
Overall design The post partial hepatectomy mice liver cells were fixed and isolated, analysis of genomic occupancy of E2f4,H3K4me2,H3K27ac in hepatocytes from Arid1a WT and Arid1a liver specific KO mice by ChIP-seq.
Contributor(s) Sun X, Xing C, Kanchwala M, Zhu H
Citation(s) 27044474
Submission date Jan 15, 2016
Last update date May 15, 2019
Contact name Xuxu Sun
Organization name shanghai jiao tong university
Department school of medicine
Street address 227 south chongqing road
City shanghai
ZIP/Postal code 200025
Country China
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (16)
GSM2040953 postPHX-E2f4-WT rep1
GSM2040954 postPHX-E2f4-WT rep2
GSM2040955 postPHX-E2f4-KO rep1
This SubSeries is part of SuperSeries:
GSE76935 Suppression of SWI/SNF component Arid1a promotes mammalian regeneration through chromatin remodeling
BioProject PRJNA308951
SRA SRP068518

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Supplementary file Size Download File type/resource
GSE76927_RAW.tar 1.1 Gb (http)(custom) TAR (of BIGWIG, BROADPEAK, NARROWPEAK)
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Raw data are available in SRA
Processed data provided as supplementary file

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