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Series GSE76826 Query DataSets for GSE76826
Status Public on Jan 14, 2016
Title Blood transcriptomic markers in patients with late-onset major depressive disorder
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Search for the biomarkers of major depressive disorder (MDD) has facilitated from the genes expressed in the patient’s blood cells. Because the severity of depressive symptoms and characteristics in patients with MDD are differed by the age at onset of first depressive episode, the potential transcriptomic markers in blood cells may also be different by the age at onset of MDD. In this study, we searched the transcriptomic markers of late-onset (onset ages ≥ 50 years) MDD (LOD) from the expressed genes in blood cells, and identified state-dependent biomarkers in the patients. We assessed the expressed genes in blood cells by the microarray and found that the expression levels of 3,066 probes were state-dependently changed in the blood cells of patients with LOD.
Overall design Elderly (age ≥50 years) outpatients and inpatients with MDD corresponding to a DSM-IV diagnosis of the melancholy type of MDD episodes were studied. The depressive state was measured using the Structured Interview Guide for the Hamilton Depression (SIGH-D) rating scale. Syndromal remission was defined as a stage in which a participant did not meet the diagnosis of a MINI major depressive episode for a period of 2 consecutive months and had a SIGH-D score of less than 8. Twelve healthy individuals were also recruited. Blood was obtained from the participants and analyzed using an Agilent SurePrint G3 Human GE 8×60K v2 Microarray (Design ID: 039494).
Contributor(s) Miyata S, Okano Y, Sakurai N, Takahashi K, Narita K, Fukuda M, Mikuni M
Citation(s) 26926397
Submission date Jan 13, 2016
Last update date Jan 09, 2018
Contact name Shigeo Miyata
Organization name Gunma University Graduate School of Medicine
Street address 3-39-22 Showa-machi
City Maebashi
ZIP/Postal code Gunma 371-8511
Country Japan
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (32)
GSM2038455 HC_1
GSM2038456 HC_2
GSM2038457 HC_3
BioProject PRJNA308732

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE76826_RAW.tar 391.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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