NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE76738 Query DataSets for GSE76738
Status Public on Jan 11, 2016
Title Transcriptome profiling in knock-in mouse models of Huntington's disease. [gonadal adipose miRNA]
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 6 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals
 
Overall design miRNA expression profiles were obtained via RNA-seq analysis performed on samples from the White Adipose tissue around Gonad of 6 month old knock-in mice with CAG lengths of 20, 80, 92, 111, 140, 175 along with littermate control wild-type animals.
 
Contributor(s) Aaronson J, Rosinski J
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jan 11, 2016
Last update date May 15, 2019
Contact name Jeff Aaronson
E-mail(s) jeff.aaronson@chdifoundation.org
Phone (609) 945-9616
Organization name CHDI
Department Discovery & Systems Biology
Street address 155 Village Boulevard, Suite 200
City Princeton
State/province New Jersey
ZIP/Postal code 08540
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (52)
GSM2036976 Het (Q111) 6 months Female White Adipose (Gonad) miRNA rep1
GSM2036977 Het (Q111) 6 months Female White Adipose (Gonad) miRNA rep2
GSM2036978 Het (Q111) 6 months Female White Adipose (Gonad) miRNA rep3
This SubSeries is part of SuperSeries:
GSE76753 Transcriptome profiling in knock-in mouse models of Huntington's disease [gonadal adipose mRNA and miRNA]
Relations
BioProject PRJNA308527
SRA SRP068385

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE76738_GonadalAdipose_6month_miRNA_Count.xlsx.gz 276.5 Kb (ftp)(http) XLSX
GSE76738_GonadalAdipose_6month_miRNA_RPKM.xlsx.gz 416.3 Kb (ftp)(http) XLSX
SRA Run SelectorHelp
Processed data are available on Series record
Raw data are available in SRA
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap