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Series GSE75767 Query DataSets for GSE75767
Status Public on Dec 08, 2015
Title Type I and type II interferon coordinately regulate suppressive dendritic cell fate and function during viral persistence
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We identified a population of immunosuppressive dendritic cells (iregDCs) that arises during LCMV-Cl13 infection. IregDCs have a distinct lineage, functional activity, and RNA expression profile compared to stimulatory dendritic cells (stimDCs) that are present within the same environment. While both are CD11b+ DCs, iregDCs develop from monocytes and stimDCs develop from conventional DC (cDC) precursors. IregDCs and stimDCs also respond differently to type I interferon (IFN-I) stimulation. IregDCs respond to IFN-I by upregulating the expression of immunosuppressive ligands while IFN-I blunts the expansion and proliferation of the stimDC population. The gene expression profiles of iregDCs and stimDCs overlap in many areas, however the production of many chemokines and cytokines as well as stimulatory and inhibitory cell surface ligands are quite distinct resulting in two dendritic cell populations with drastically different functions.
Overall design The comparison of RNA expression profiles between immunosuppressive and stimulatory dendritic cells together with their naïve progenitors (monocytes and naïve dendritic cells, respectively)
Contributor(s) Cunningham CR, Champhekar A, Smale ST, Brooks DG
Citation(s) 26808628
Submission date Dec 07, 2015
Last update date May 15, 2019
Contact name Ameya Champhekar
Organization name University of California, Los Angeles
Department Medicine, HemOnc Division
Street address 700 Tiverton Ave, 11-272 Factor Bldg
City Los Angeles
State/province California
ZIP/Postal code 90095-1678
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (4)
GSM1967127 Dendritic cells from uninfected mice
GSM1967128 Monocytes from uninfected mice
GSM1967129 Immunosuppressive dendritic cells from LCMV-Cl13 infected mice
BioProject PRJNA305300
SRA SRP067084

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Supplementary file Size Download File type/resource
GSE75767_combined_rpkm_table.txt.gz 358.5 Kb (ftp)(http) TXT
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