|
| Status |
Public on Jan 01, 2017 |
| Title |
Effect of PD-1 immune checkpoint in Alzheimer's disease transgenic mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We examined the brain's choroid plexus and myeloid cell populations isolated from the brain of 5XFAD Alzheimer's disease transgenic mice following PD-1 blockade
|
| |
|
| Overall design |
Choroid plexus samples and myeloid cell populations were isolated from the brain of 5XFAD mice following PD-1 blockade, and sequenced. For choroid plexus samples, 5 mice were treated with anti-PD-1, 5 with IgG control, and 4 were left untreated. For the myeloid cells samples, myeloid cells sorted from the brains of 5XFAD mice according to a gating strategy that seperate microglia (CD11b+CD45-low) and monocytes-derived macrophages (CD11b+CD45-high).
|
| |
|
| Contributor(s) |
Baruch K, David E |
| Citation(s) |
26779813 |
| |
| Submission date |
Nov 30, 2015 |
| Last update date |
Aug 08, 2023 |
| Contact name |
Ido Amit |
| E-mail(s) |
ido.amit@weizmann.ac.il
|
| Phone |
972-8-9343338
|
| Organization name |
Weizmann Institute of Science
|
| Department |
Immunology
|
| Street address |
234 Herzl st.
|
| City |
Rehovot |
| ZIP/Postal code |
760001 |
| Country |
Israel |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (25)
|
|
| Relations |
| BioProject |
PRJNA304412 |
| SRA |
SRP066786 |
Less...
More...