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| Status |
Public on Feb 27, 2008 |
| Title |
Treatment of primary acute myelogenous leukemia (AML) specimens with parthenolide (PTL) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The effects of 7.5 micromolar parthenolide (PTL) were assessed on primary CD34+ acute myelogenous leukemia specimens obtained from 12 patients.
Keywords: drug response, gene expression search agent
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| Overall design |
Acute myelogenous leukemia (AML) specimens were obtained from 12 patients and CD34+ cells were isolated. For each patient, cells were cultured in vitro and exposed to either 7.5 micromolar parthenolide (PTL) or left untreated (UT) for 6 h. Total RNA was then harvested for global gene expression analysis.
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| Contributor(s) |
Hassane DC, Guzman ML, Li X, Corbett C, Abboud R, Young F, Liesveld JL, Carroll M, Jordan CT |
| Citation(s) |
18305216, 24934933, 27888238 |
| Submission date |
Apr 17, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Duane Hassane |
| Organization name |
Weill Cornell Medical College
|
| Street address |
1305 York Avenue, Box 140
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10021 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA99367 |
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