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Series GSE74995 Query DataSets for GSE74995
Status Public on Jan 26, 2016
Title Cortex PS2 APP transgenic mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gene Expression profiles from whole cortical tissue from the PS2APP transgenic mouse model of Alzheimer's disease will reflect the cellular alterations, including the pathological drivers and the compensatory mechanisms of neurodegeneration when compared to wild-type control animals.
The "SAMID" sample characteristic is a sample identifier internal to Genentech.
The ID of this project in Genentech's ExpressionPlot database is PRJ0006684

Keywords: Expression profiling by array
Overall design 5 Male transgenic and 5 Male wild-type mice were perfused and sacrificed at 3 months (earliest behavioral changes), 7 months (inflammation and plaque pathology), or 13 months (spreading synapse loss) of age. Hemicortices were subdissected and flash frozen prior to RNA extraction using the RNeasy Lipid Tissue extraction kit with on-column Dnase digestion.
Contributor(s) Friedman B, Lauffer B, Hansen D
Citation(s) 27097852
Submission date Nov 13, 2015
Last update date Nov 01, 2017
Contact name Brad A Friedman
Organization name Genentech, Inc.
Department Bioinformatics
Street address 1 DNA Way
City South San Francisco
State/province CA
ZIP/Postal code 94133
Country USA
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (30)
GSM1940056 WT 13 months SAM14136225
GSM1940057 PS2APP 3 months SAM14136232
GSM1940058 PS2APP 7 months SAM14136235
BioProject PRJNA302153

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74995_RAW.tar 129.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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