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Series GSE74959 Query DataSets for GSE74959
Status Public on Feb 22, 2016
Title Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [human cell line gene expression]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence.
Overall design Identify the KDM2B dependent transcriptome in human leukemia cell lines by using the GeneChip® PrimeView™ Human Gene Expression Array
Contributor(s) Tzatsos A, Kai Y
Citation(s) 26808549
Submission date Nov 12, 2015
Last update date Aug 23, 2018
Contact name Alexandros Tzatsos
Phone 2029949104
Organization name George Washington University
Department GW Cancer Center
Lab Cancer Epigenetics Laboratory
Street address 800 22nd St NW SEH 8850
City Washington
State/province DC
ZIP/Postal code 20052
Country USA
Platforms (1)
GPL15207 [PrimeView] Affymetrix Human Gene Expression Array
Samples (16)
GSM1939025 ALLSIL shControl_1
GSM1939026 ALLSIL shControl_2
GSM1939027 ALLSIL shKDM2B_1
This SubSeries is part of SuperSeries:
GSE70729 Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies
BioProject PRJNA302011

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74959_RAW.tar 38.5 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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