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Series GSE74734 Query DataSets for GSE74734
Status Public on Mar 08, 2016
Title An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Changes in cellular metabolism contribute to the development and progression of tumors, and can render tumors vulnerable to interventions. However, studies of human cancer metabolism remain limited due to technical challenges of detecting and quantifying small molecules, the highly interconnected nature of metabolic pathways, and the lack of designated tools to analyze and integrate metabolomics with other –omics data. Our study generates the largest comprehensive metabolomics dataset on a single cancer type, and provides a significant advance in integration of metabolomics with sequencing data. Our results highlight the massive re-organization of cellular metabolism as tumors progress and acquire more aggressive features. The results of our work are made available through an interactive public data portal for cancer research community.
Overall design 10 RNA samples from human ccRCC tumors analyzed from the high glutathione cluster
Contributor(s) Hakimi AA, Reznik E, Hsieh J
Citation(s) 26766592
Submission date Nov 05, 2015
Last update date May 15, 2019
Contact name Jeffrey Zhao
Organization name Memorial Sloan Kettering Cancer Center
Department Genomics Core
Street address 1275 York Avenue
City New York
State/province NY
ZIP/Postal code 10065
Country USA
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (10)
GSM1931335 Pt 113
GSM1931336 Pt 165
GSM1931337 Pt 183
BioProject PRJNA301435
SRA SRP065894

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74734_kirc_gene_counts.txt.gz 653.2 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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