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Series GSE74704 Query DataSets for GSE74704
Status Public on Oct 31, 2018
Title CSMD1 shows complex somatic alterations in esophageal squamous cell carcinoma based on a pilot integrated analysis [Affy_500K]
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Genome variation profiling by SNP array
Summary Since ESCC is a complex and heterogeneous disease, it is increasingly important that analyses combine the evaluation of alterations in DNA, including somatic copy number alterations (SCNA), which distinguished from germ line copy number variants, allelic imbalance and LOH, and RNA, including those that occur in both mRNA and miRNA on the same specimen. Thus, in order to better understand their potential interactions in the development of cancers, in the present study, we studied alterations at DNA level as well as expression of mRNA and target miRNA in tumors and their matched normal tissues from 56 ESCC cases on a candidate tumor suppressor gene CSMD1 to characterize there alterations in this gene for import insights into the cellular detect that cause the complex disease, ESCC.
 
Overall design Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from esophageal squamous cell carcinoma diagnosed or peripheral blood samples.
 
Contributor(s) Wang C, Yang H
Citation(s) 36291785
Submission date Nov 05, 2015
Last update date Nov 02, 2022
Contact name Howard Yang
E-mail(s) yanghow@mail.nih.gov
Phone 2402765257
Organization name NCI
Street address 9609 Medical Center Dr.
City Rockville
State/province MD
ZIP/Postal code 20850
Country USA
 
Platforms (2)
GPL3718 [Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array
GPL3720 [Mapping250K_Sty] Affymetrix Mapping 250K Sty2 SNP Array
Samples (80)
GSM1930536 ESCC_GE024B_Nsp
GSM1930537 ESCC_GE024B_Sty
GSM1930538 ESCC_GE024T_Nsp
This SubSeries is part of SuperSeries:
GSE74705 CSMD1 shows complex somatic alterations in esophageal squamous cell carcinoma based on a pilot integrated analysis
Relations
BioProject PRJNA301208

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74704_RAW.tar 1.9 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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