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Series GSE74666 Query DataSets for GSE74666
Status Public on Aug 01, 2016
Title Comparation the mRNA Expression Profile of the MV4-11 Sorafenib Resistant Cells and the Parental Cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Our gene set analysis of MV4-11-R versus MV4-11 indicated decreased depolarization of mitochondria and mitochondrial membrane, mitochondrial dysfunction and anti-apoptosis as other top ranked molecular or cellular functions of differential gene sets. expression of most genes encoding glycolytic enzymes was up-regulated in MV4-11-R cells we revealed a metabolic alteration in sorafenib-resistant cell lines with mitochondrial respiration deficiency, leading to substantial decrease of mitochondria-derived ATP generation and a significant increase in glycolytic activity to maintain sufficient ATP production. Our study revealed a metabolic signature of sorafenib resistance and indicated that increase of glycolytic activity including upregulation of major glycolytic enzymes may be viewed as a marker for early detection of sorafenib resistance in AML patients with FLT3/ITD mutation and glycolytic inhibitors warrant further investigation as alternative therapeutic agents for sorafenib-resistant cells
Overall design Sorafenib resistant cells MV411-R VS. parental MV4-11 cells. Biological replicates: 3 control replicates, 3 treated replicates.
Contributor(s) Huang A, Hu Y
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Submission date Nov 04, 2015
Last update date Jan 09, 2018
Contact name Amin Huang
Organization name Sun Yat-sen University Cancer Center
Street address 651 Dongfengdong East Rd
City Guangzhou
ZIP/Postal code 510060
Country China
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (6)
GSM1925985 253949410922-1-1 [MV4-11]
GSM1925986 253949410922-1-2 [MV4-11]
GSM1925987 253949410922-1-3 [MV4-11]
BioProject PRJNA301124

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74666_RAW.tar 74.8 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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