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Series GSE74418 Query DataSets for GSE74418
Status Public on Nov 04, 2015
Title Gene expression profiles of prostate cancer cell line with or without HDAC inihbitors
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Histone deacetylase (HDAC) inibitors suppress cell proliferation of prostate cancer, but the detailed mechanisms are unknown. Moreover, HDAC includes 18 family members, namely HDAC1-11 and SIRT1-7, and differences of effects on prostate cancer proliferation among these enzymes are also unknown. Thus, we clarified differences of gene expression between prostate cancer cell line (LNCaP) treated with pan-HDAC inhibitors (TSA and OBP-801) or selective HDAC inhibitor (NCC-149, HDAC8-specific inhibitor)using cDNA microarray.
Overall design LNCaP treated with TSA (1μM), NCC149 (2μM), OBP-801 (200nM) or DMSO for 24hrs, RNA was extracted from cells, and cDNA array was performed.
Contributor(s) Sato S
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Submission date Oct 28, 2015
Last update date Nov 27, 2018
Contact name Shinya Sato
Organization name Nagoya City University
Street address kawasumi1, mizuho-ku
City Nagoya
ZIP/Postal code 467-8601
Country Japan
Platforms (1)
GPL13607 Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version)
Samples (12)
GSM1920182 LNCaP treated with TSA1
GSM1920183 LNCaP treated with TSA2
GSM1920184 LNCaP treated with TSA3
BioProject PRJNA300937

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74418_RAW.tar 42.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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