|
| Status |
Public on Nov 04, 2015 |
| Title |
Gene expression profiles of prostate cancer cell line with or without HDAC inihbitors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Histone deacetylase (HDAC) inibitors suppress cell proliferation of prostate cancer, but the detailed mechanisms are unknown. Moreover, HDAC includes 18 family members, namely HDAC1-11 and SIRT1-7, and differences of effects on prostate cancer proliferation among these enzymes are also unknown. Thus, we clarified differences of gene expression between prostate cancer cell line (LNCaP) treated with pan-HDAC inhibitors (TSA and OBP-801) or selective HDAC inhibitor (NCC-149, HDAC8-specific inhibitor)using cDNA microarray.
|
| |
|
| Overall design |
LNCaP treated with TSA (1μM), NCC149 (2μM), OBP-801 (200nM) or DMSO for 24hrs, RNA was extracted from cells, and cDNA array was performed.
|
| |
|
| Contributor(s) |
Sato S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 28, 2015 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Shinya Sato |
| E-mail(s) |
hiroshima53@gmail.com
|
| Organization name |
Nagoya City University
|
| Street address |
kawasumi1, mizuho-ku
|
| City |
Nagoya |
| ZIP/Postal code |
467-8601 |
| Country |
Japan |
| |
|
| Platforms (1) |
| GPL13607 |
Agilent-028004 SurePrint G3 Human GE 8x60K Microarray (Feature Number version) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA300937 |
Less...
More...