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| Status |
Public on Feb 15, 2008 |
| Title |
Early Response and Outcome in High-Risk Childhood Acute Lymphoblastic Leukemia: A Children’s Oncology Group Study |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The cure rate for childhood ALL has improved considerably in part because therapy is routinely tailored to the predicted risk of relapse. Various clinical and laboratory variables are used in current risk-stratification schemes, but many children who fail therapy lack adverse prognostic factors at initial diagnosis. Using gene expression analysis, we have identified genes and pathways in a NCI high-risk childhood B-precursor ALL cohort at diagnosis that may play a role in early blast regression as correlated with the Day 7 marrow status. We have also identified a 47-probeset signature (representing 41 unique genes) that was predictive of long term outcome in our dataset as well as three large independent datasets of childhood ALL treated on different protocols.
Keywords: ordered, case-control
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| Overall design |
Diagnostic marrow samples from 99 children with NCI high risk B-precursor ALL treated on the protocol COG 1961 were analyzed. To study genetic profiles associated with early response to therapy, 82 of the total 99 patients were analyzed: 42 patients with a M1 marrow at day 7 of therapy were compared to 40 patients with a M3 marrow at day 7. To study the genes associated with long-term outcome, expression profiles of 59 (of the total 99) patients were analyzed: 28 patients who remained in complete continuous remission (CCR) for at least 4 years and 31 patients who suffered a bone marrow relapse within the first 3 years of initial diagnosis. Forty-two patients were common in both the early response and outcome analyses.
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| Contributor(s) |
Bhojwani D, Carroll WL |
| Citation(s) |
18802149 |
| Submission date |
Apr 03, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Deepa Bhojwani |
| E-mail(s) |
deepa.bhojwani@med.nyu.edu
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| Organization name |
New York University School of Medicine
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| Department |
Pediatric Hematology Oncology
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| Street address |
Smilow Research Building 1206-B, 522 First Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (99)
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| Relations |
| BioProject |
PRJNA100235 |
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