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Series GSE74279 Query DataSets for GSE74279
Status Public on Oct 23, 2015
Title Positional proteomics reveals differences in N-terminal proteoform stability
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To understand the impact of alternative translation initiation on a proteome, we performed the first study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes. Overall, we monitored the stability of 1,941 human N-terminal proteoforms, including 147 N-terminal proteoform pairs that originate from alternative translation initiation, alternative splicing or incomplete processing of the initiator methionine.
Overall design Ribosome profiling of lactimidomycin and cycloheximide treated human Jurkat T-lymphocytes
Contributor(s) Gawron D, Ndah E, Gevaert K, Van Damme P
Citation(s) 26893308
BioProject PRJNA299254
Submission date Oct 22, 2015
Last update date May 15, 2019
Contact name Petra Van Damme
Phone +3292649279
Organization name VIB
Street address Albert Baertsoenkaai 3
City Gent
ZIP/Postal code 9000
Country Belgium
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (2)
GSM1916181 Lactimidomycin treated Jurkat cells
GSM1916182 Cycloheximide treated Jurkat cells
SRA SRP065022

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Supplementary file Size Download File type/resource
GSE74279_RAW.tar 136.8 Mb (http)(custom) TAR (of BEDGRAPH)
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Raw data are available in SRA
Processed data provided as supplementary file

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