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Series GSE74049 Query DataSets for GSE74049
Status Public on Oct 16, 2015
Title Transcriptome Analysis Identifies Linc-Yy1, A Novel Functional LincRNA During Myogenesis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary Little is known how lincRNAs are involved in skeletal myogenesis. Here we describe the discovery of a novel lincRNA, Linc-YY1 from the promoter of transcription factor (TF) Yin Yang 1 (YY1) gene. We demonstrate that Linc-YY1 is dynamically regulated during myogenesis in vitro and in vivo. Gain or loss of function of Linc-YY1 in C2C12 myoblast cells or satellite cells alters myogenic differentiation and in injured muscles impacts the course of regeneration. Further studies suggest LincYY1 may interact with YY1 through its middle domain to evict YY1
Overall design 9 ChIP-seq and 4 RNA-seq experiments performed
Contributor(s) Wang H, Sun H, Zhou L, Sun K, Zhao Y
Citation(s) 26658965, 26981420
Submission date Oct 15, 2015
Last update date May 15, 2019
Contact name Kun Sun
Organization name Shenzhen Bay Laboratory
Department Cancer Research
Lab Kun Sun
Street address Rm B505, No. 9 Duxue Road, Nanshan District
City Shenzhen
ZIP/Postal code 518107
Country China
Platforms (3)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (13)
GSM1908734 GM_RNA-seq
GSM1908735 DM_RNA-seq
GSM1908736 siNC_RNA-seq
BioProject PRJNA298863
SRA SRP064842

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE74049_RAW.tar 2.1 Mb (http)(custom) TAR (of BEDGRAPH, TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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