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Series GSE73598 Query DataSets for GSE73598
Status Public on Oct 01, 2015
Title Expression data from cardiac stem cells (CSCs) with or without MSC-exosomes treatment
Platform organism synthetic construct
Sample organism Rattus norvegicus
Experiment type Non-coding RNA profiling by array
Summary Cardiac resident c-kit+ cells aroused much interest among the cardiologists at the beginning of the century. These cells are selfrenewing, clonogenic, and multipotent and possess the potential to differentiate into all cardiovascular lineages. However, one of the critical problems faced by c-kit+ cells is the poor engraftment and survival after transplantation. Therefore, researchers are focusing on developing next generation CSC products that will enhance the engraftment, survival, and regenerative capabilities of these cells. Considering this, we made a proposal that cardiac stem cells preconditioned with exosomes derived from bone marrow mesenchymal stem cells could survive and function better in a myocardial infarction model.
Overall design We isolated and characterized exosomes from MSCs and evaluated their effects on CSCs in vitro and in vivo.
We compared the miRNA expression profiling on CSCs with or without MSC-exosomes treatment.
Contributor(s) Zhang Z, Yang J
Citation(s) 26811168
Submission date Sep 30, 2015
Last update date May 02, 2017
Contact name Junjie Yang
Phone 0086-532-67780948
Organization name Institute for cardiovascular science of Soochow University
Street address 708 Renmin Road
City Suzhou
ZIP/Postal code 215006
Country China
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (6)
GSM1898767 CSC+Exo 1
GSM1898768 CSC+Exo 2
GSM1898769 CSC+Exo 3
BioProject PRJNA297407

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE73598_Differential_miRNAs_and_note.xlsx 18.2 Kb (ftp)(http) XLSX
GSE73598_RAW.tar 4.5 Mb (http)(custom) TAR (of CEL)
GSE73598_Target_genes_predicted_by_miranda.xlsx 749.7 Kb (ftp)(http) XLSX
Processed data included within Sample table
Processed data are available on Series record

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