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Series GSE73394 Query DataSets for GSE73394
Status Public on Dec 31, 2018
Title BAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells (III)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Background: We got interested whether genes of airway basal cells are enriched in sarcoidosis.

Methods: Bronchoscopy with bronchoalveolar lavage (BAL) was performed in 26 patients with sarcoidosis, chest-x-ray type III and IV, and 20 healthy donors and isolated BAL cells.Transcriptome of BAL cells were studied by using Affymetrix Human Affymetrix Whole-Transcript Human Gene 1.0 ST array on an Affymetrix platform. Microarray data were imported, log2-transformed and quantile normalized using robust multi-array average (RMA). We tested enrichment for airway basal cells by global enrichment analysis.

Results: we did not find enrichment of airway basal cell genes in sarcoidosis compared to healthy volunteers.
 
Overall design Microarray data of BAL cells from 26 patients with sarcoidosis and 20 healthy volunteers were obtained. We tested for enrichment of genes highly expressed in airway basal cells and identified in GSE70864
Please note that sarcoidosis stage information for each individual patient was not provided since the information was not considered for the statistical data analysis.
 
Contributor(s) Prasse A, Violette S
Citation(s) 30141961
Submission date Sep 24, 2015
Last update date Apr 03, 2019
Contact name Antje Prasse
Organization name Medical School Hannover
Department Pneumology
Lab Prasse OE6870
Street address Carl-Neubergstrasse 1
City Hannover
ZIP/Postal code 30625
Country Germany
 
Platforms (1)
GPL10739 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [probe set (exon) version]
Samples (46)
GSM1892482 BAL_SARC_1
GSM1892483 BAL_SARC_2
GSM1892484 BAL_SARC_3
This SubSeries is part of SuperSeries:
GSE70867 BAL cell gene expression is predictive of Mortality in Idiopathic Pulmonary Fibrosis and enriched for Genes of Airway Basal Cells
Relations
BioProject PRJNA296875

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE73394_RAW.tar 194.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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