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Series GSE73290 Query DataSets for GSE73290
Status Public on May 18, 2016
Title Hepatic transcriptome of mice fed high fat diets containing palm or linseed oil
Organism Mus musculus
Experiment type Expression profiling by array
Summary The beneficial effects of dietary long-chain (LC) n-3 polyunsaturated fatty acids (PUFA) in the prevention and/or treatment of some metabolic disorders result largely from their capacity to regulate the transcription level of many genes involved in metabolic and physiological homeostasis, especially in the liver. In this respect, they are known to bind and activate the Peroxisome Proliferator-Activated Receptor alpha (PPARalpha). The precursor of LC-PUFA, a-linoleic acid (ALA, C18:3 n-3) share some beneficial metabolic effects with its LC derivatives, however its role in gene regulation is poorly documented. Here, we analysed the hepatic transcriptome of mice fed for 5 weeks diets rich in either saturated FA from palm oil (PALM group) or ALA from linseed oil (LIN group). This modification of dietary fatty acid composition in a context of a high fat diet had a subtle but significant effect on the hepatic transcriptome. We identified mainly a group of genes that were upregulated in the LIN vs the PALM group and that include several well-known PPARalpha target genes involved in lipid and xenobiotic metabolism.
Overall design Liver gene expression was measured in male C57BL/6J mice fed during 5 weeks a high fat diet (51% energy from fat) containing palm oil, rich in saturated fatty acids (n=10) or linseed oil, rich in 18:3 n-3 (n=8)
Contributor(s) Martin PG, Guelzim N, Lasserre F, Lippi Y, Hermier D
Citation(s) 27178023
Submission date Sep 21, 2015
Last update date Nov 01, 2017
Contact name Pascal GP Martin
Organization name INRAE
Department UMR1332 BFP
Street address 71 avenue Edouard Bourlaux
City Villenave d'Ornon
ZIP/Postal code 33140
Country France
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (18)
GSM1890187 Liver_LINdiet_rep1
GSM1890188 Liver_LINdiet_rep2
GSM1890189 Liver_LINdiet_rep3
BioProject PRJNA296535

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Supplementary file Size Download File type/resource
GSE73290_RAW.tar 159.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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