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Series GSE73080 Query DataSets for GSE73080
Status Public on Sep 19, 2015
Title Transcriptome data of multiple sclerosis patients receiving fingolimod therapy [HTA-2_0, CD4+ cells, exon level]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We analyzed the gene expression patterns of different blood cell types before and during fingolimod treatment in a group of patients with relapsing-remitting multiple sclerosis (RRMS).
Affymetrix Human Transcriptome Arrays (HTA) 2.0 were used to obtain gene expression profiles of immune cell populations from 10 RRMS patients within the first 3 months of fingolimod treatment.
This GEO entry provides the Affymetrix HTA 2.0 microarray data of peripheral blood CD4+ cells, preprocessed according to the exon level workflow.
Overall design EDTA blood samples were taken from all patients immediately before first and second fingolimod administration as well as after 3 months of therapy.
Total RNA of CD4+ cells positively selected from each blood sample was extracted, labeled and hybridized to high-density Affymetrix HTA 2.0 microarrays to quantify the transcript levels.
Contributor(s) Hecker M, Koczan D, Zettl UK
Citation(s) 28155899, 29314605, 30040082
Submission date Sep 16, 2015
Last update date Jul 26, 2018
Contact name Michael Hecker
Organization name University of Rostock
Department Department of Neurology
Lab Division of Neuroimmunology
Street address Gehlsheimer Str. 20
City Rostock
ZIP/Postal code 18147
Country Germany
Platforms (1)
GPL17585 [HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [probe set (exon) version]
Samples (30)
GSM1884983 Patient 1, CD4+ cells, before first dose of fingolimod [exon-level]
GSM1884984 Patient 1, CD4+ cells, before second dose of fingolimod [exon-level]
GSM1884985 Patient 1, CD4+ cells, after 3 months of fingolimod treatment [exon-level]
This SubSeries is part of SuperSeries:
GSE73174 Transcriptome data of multiple sclerosis patients receiving fingolimod therapy
BioProject PRJNA296111

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Supplementary file Size Download File type/resource
GSE73080_RAW.tar 919.4 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table

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