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Series GSE72250 Query DataSets for GSE72250
Status Public on Apr 08, 2016
Title Characterization of chromatin accessibility through the DNaseI hypersensitivity assay in breast cancer cells treated with either Dex or E2
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1 (FoxA1) are significant factors in breast cancer progression. FoxA1 is well-established as a pioneer factor for steroid receptor recruitment to chromatin. Here we show that ER and GR have the ability to alter the genomic response of FoxA1 to specific binding sites within the genome. These findings alter the classical understood mechanism of FoxA1 establishing a dynamic transcription factor that can be regulated by hormones.
Overall design We examined the ER and GR mediated affects on FoxA1 binding patterms
Contributor(s) Swinstead EE, Baek S, Hager GL
Citation(s) 27062924
Submission date Aug 20, 2015
Last update date May 15, 2019
Contact name Songjoon Baek
Organization name NCI / NIH
Department CCR
Street address 41 Library Drive
City Bethesda
State/province MD
ZIP/Postal code 20892
Country USA
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (12)
GSM1858661 untreated rep#1 DNase-seq GH1501
GSM1858662 untreated rep#2 DNase-seq GH1571
GSM1858663 Dex rep#1 DNase-seq GH1502
This SubSeries is part of SuperSeries:
GSE72252 DNaseI hypersensitivity assay and ER, GR, and FoxA1 binding patterns in breast cancer cells
BioProject PRJNA293470
SRA SRP062678

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Supplementary file Size Download File type/resource
GSE72250_RAW.tar 1.4 Gb (http)(custom) TAR (of BEDGRAPH)
GSE72250_hs_RC_MCF7_DHS_Dex_RC_GH1502_3xGH1572_3_FDR0.csv.gz 2.1 Mb (ftp)(http) CSV
GSE72250_hs_RC_MCF7_DHS_E2_RC_GH1503_3xGH1573_3_FDR0.csv.gz 2.0 Mb (ftp)(http) CSV
GSE72250_hs_RC_MCF7_DHS_unt_RC_GH1501_3xGH1571_3_FDR0.csv.gz 2.0 Mb (ftp)(http) CSV
GSE72250_hs_RC_ZR-75-1_Dex_RC_GH1564xGH1568_FDR0.csv.gz 2.7 Mb (ftp)(http) CSV
GSE72250_hs_RC_ZR-75-1_E2_RC_GH1565xGH1569_FDR0.csv.gz 2.3 Mb (ftp)(http) CSV
GSE72250_hs_RC_ZR-75-1_untreated_RC_GH1563xGH1567_FDR0.csv.gz 2.5 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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