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Series GSE71738 Query DataSets for GSE71738
Status Public on Aug 06, 2015
Title Molecular hydrogen stimulates the gene expression of a translational coactivator PGC-1alpha to enhance fatty acid metabolism
Organism Mus musculus
Experiment type Expression profiling by array
Summary We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibits multiple-functions. Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice, accompanied with the increased gene expression of an energy metabolism stimulatory hepatic hormone, fibroblast growth factor 21 (FGF21); however, the molecular mechanism is unknown particularly on whether this gene regulation is a primary cause or the secondary consequence. Pathway analyses based on comprehensive gene expression revealed the increased expression in various genes involved in fatty acid and steroid metabolisms. As a transcription pathway, the PPARa signaling pathway was identified to up-regulate the genes by 14 day-ingestion of H2. As an early event, the gene expression of PGC-1a was transiently increased at day 3, followed by increased expression of FGF21. In wild-type mice that fed with fatty-diet, H2-water improved the level of plasma triglyceride and extended their life span.
Overall design H2 was ingested by ad libitum drinking H2-water for 14 days or by oral administration of an H2-producing material MgH2 for 1, 3 or 7 days. Comprehensive gene expression profile in liver of db/db mice was analyzed by DNA microarray.
Contributor(s) Kamimura N, Ichimiya H, Ohta S
Citation(s) 28721265
Submission date Aug 05, 2015
Last update date Jul 11, 2019
Contact name Shigeo Ohta
Phone +81-44-733-9267
Organization name Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School
Department Department of Biochemistry and Cell Biology
Street address 1-394, Kosugi-machi, Nakahara-ku
City Kawasaki-city
State/province Kanagawa
ZIP/Postal code 211-8533
Country Japan
Platforms (1)
GPL10333 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Feature Number version)
Samples (12)
GSM1844428 cont_vs_H2_2weeks_rep1
GSM1844429 cont_vs_H2_2weeks_rep2
GSM1844430 cont_vs_H2_2weeks_rep3
BioProject PRJNA291974

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71738_RAW.tar 56.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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