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Series GSE71123 Query DataSets for GSE71123
Status Public on May 04, 2017
Title MeDIP assay using human myometrium of women with preterm labor of different phenotypes vs. normal term labor
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Summary Preterm birth is multifactorial in origin with several distinct clinical phenotypes of differing etiologies, including idiopathic preterm birth. Preterm birth involves the interaction of genetic, societal and environmental factors such as nutrition, lifestyle and stress that may modulate the length of gestation via the epigenome. DNA methylation is a well-studied epigenetic modification whereby promoter methylation commonly represses gene expression and vice versa.
Myometrial tissue was obtained at cesarean section at term with or without labor, preterm without labor, idiopathic preterm labor, and twin gestations with labor. Differences in the myometrial epigenomes were identified at gene promoters, CpG islands, CpG island shores and shelves, gene bodies across the genome between the groups of women with preterm labor of different phenotypes vs. normal term labor. Functional clustering analysis indicated the significantly enriched pathways of hypomethylated genes (permissive) were related to acute inflammatory and acute-phase responses. By contrast, genes that are hypermethylated (repressive) revealed enrichment for contractile fibers and cell. This study provides the first high-resolution DNA methylome of human myometrium with evidence for differences in the methylome that may relate to idiopathic preterm birth via regulation of gene expression. The findings extend previous observations that idiopathic preterm labor is associated with subclinical intrauterine infection and inflammatory pathways and point to targets for further molecular characterization of preterm delivery.
Overall design Comparison of the human myometrial epigenomes in pregnancies with preterm labor of different phenotypes vs. normal term labor
Contributor(s) Mitsuya K, Myatt L
Citation(s) 24571989
Submission date Jul 20, 2015
Last update date Aug 01, 2019
Contact name Kohzoh Mitsuya
Phone 210-567-7064
Organization name University of Texas Health Science Center San Antonio
Department Center for Pregnancy and Newborn Research
Lab Leslie Myatt
Street address 7703 Floyd Curl Drive
City San Antonio
State/province Texas
ZIP/Postal code 78229-3900
Country USA
Platforms (1)
GPL16284 NimbleGen Human DNA Methylation 2.1M Deluxe Promoter Array [100929_HG19_Deluxe_Prom_Meth_HX1]
Samples (6)
GSM1827581 TL myometrial epigenome
GSM1827582 TNL-s myometrial epigenome
GSM1827583 TNL-l myometrial epigenome
BioProject PRJNA290395

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE71123_RAW.tar 846.2 Mb (http)(custom) TAR (of GFF, PAIR)
Processed data provided as supplementary file

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