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| Status |
Public on Aug 31, 2016 |
| Title |
Gene expression profiling of African-American prostate cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
African-American (AA) men have both a higher incidence and significantly higher mortality rates from prostate cancer (PCa) than European American (EA) men. In this study we have carried out a detailed analysis of both CNAs and gene expression changes in PCas from AA men compared to their matched benign tissues. We have identified MNX1 as a novel androgen regulated oncogene that is upregulated to a greater degree in AA PCa compared to EA PCa. Furthermore, RGS12 is a novel tumor suppressor on 4p16.3 that is preferentially deleted in AA PCa which negatively regulates MNX1 expression.
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| |
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| Overall design |
In this study we have carried out a detailed analysis of gene expression changes in PCas from AA men compared to their matched benign tissues.
two-group comparison
|
| Web link |
http://cancerres.aacrjournals.org/content/early/2016/08/30/0008-5472.CAN-16-0087.abstract
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| |
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| Contributor(s) |
Zhang Y, Wang J, Creighton C, Ittmann M |
| Citation(s) |
27578002 |
|
Li Zhang, Jianghua Wang, Yongquan Wang, Yiqun Zhang, Patricia Castro, Longjiang Shao, Arun Sreekumar, Nagireddy Putluri, Nilanjan Guha, Saligrama Deepak, Arunkumar Padmanaban, Chad J. Creighton, and Michael Ittmann Cancer Res; Published Online First August 30, 2016; doi:10.1158/0008-5472.CAN-16-0087
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| |
| Submission date |
Jul 16, 2015 |
| Last update date |
Apr 23, 2018 |
| Contact name |
Chad Creighton |
| E-mail(s) |
creighto@bcm.tmc.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Biostatistics, Ducan Cancer Center
|
| Street address |
One Baylor Plaza, Mail Stop: BCM305
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16699 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Feature Number version) |
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| Samples (95)
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| Relations |
| BioProject |
PRJNA290106 |
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