|
| Status |
Public on Nov 10, 2015 |
| Title |
Pancreatic Beta-Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes [ChIP-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coordinates behavior and physiology with the solar cycle. Here we reveal that the clock gates insulin secretion through genome-wide transcriptional control of the pancreatic exocyst across species. Clock transcription factors bind to unique enhancer sites in cycling genes in beta cells that diverge from those in liver, revealing the dynamics of inter-tissue clock control of genomic and physiologic processes important in glucose homeostasis.
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| |
|
| Overall design |
ChIP-Seq in Beta-TC6 mouse beta cells
|
| |
|
| Contributor(s) |
Perelis M, Marcheva B, Barish GD, Bass J |
| Citation(s) |
26542580 |
| Submission date |
Jul 15, 2015 |
| Last update date |
May 15, 2019 |
| Contact name |
Mark Perelis |
| E-mail(s) |
mperelis@u.northwestern.edu
|
| Organization name |
Northwestern University
|
| Street address |
303 E Superior Street Lurie Research Center Rm 7-220
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60611 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (8)
|
|
| This SubSeries is part of SuperSeries: |
| GSE70961 |
Pancreatic Beta Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes |
|
| Relations |
| BioProject |
PRJNA290021 |
| SRA |
SRP061204 |
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