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Series GSE70960 Query DataSets for GSE70960
Status Public on Nov 10, 2015
Title Pancreatic Beta-Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes [ChIP-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The molecular clock is a transcriptional oscillator present in brain and peripheral cells that coordinates behavior and physiology with the solar cycle. Here we reveal that the clock gates insulin secretion through genome-wide transcriptional control of the pancreatic exocyst across species. Clock transcription factors bind to unique enhancer sites in cycling genes in beta cells that diverge from those in liver, revealing the dynamics of inter-tissue clock control of genomic and physiologic processes important in glucose homeostasis.
Overall design ChIP-Seq in Beta-TC6 mouse beta cells
Contributor(s) Perelis M, Marcheva B, Barish GD, Bass J
Citation(s) 26542580
Submission date Jul 15, 2015
Last update date May 15, 2019
Contact name Mark Perelis
Organization name Northwestern University
Street address 303 E Superior Street Lurie Research Center Rm 7-220
City Chicago
State/province IL
ZIP/Postal code 60611
Country USA
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (8)
GSM1824086 BMAL1
GSM1824087 CLOCK
GSM1824088 PDX1
This SubSeries is part of SuperSeries:
GSE70961 Pancreatic Beta Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes
BioProject PRJNA290021
SRA SRP061204

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE70960_RAW.tar 2.8 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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