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Series GSE70624 Query DataSets for GSE70624
Status Public on Feb 22, 2016
Title Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies [ChIP-seq]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Development of the hematopoietic system is dynamically controlled by the interplay of transcriptional and epigenetic networks to determine cellular identity. Those networks are critical for homeostasis and frequently dysregulated in leukemias. We identified histone demethylase Kdm2b as a critical regulator of definitive hematopoiesis and lineage specification of hematopoietic stem and progenitor cells (HSPCs). RNA sequencing in murine HSPCs and genome-wide chromatin immunoprecipitation studies in human leukemias revealed that Kdm2b regulates differentiation, lineage choice, cytokine signaling, and quiescence.
Overall design Identify the binding of KDM2B in seven human leukemia cell lines
Contributor(s) Tzatsos A, Kai Y
Citation(s) 26808549
Submission date Jul 08, 2015
Last update date May 15, 2019
Contact name Alexandros Tzatsos
Phone 2029949104
Organization name George Washington University
Department GW Cancer Center
Lab Cancer Epigenetics Laboratory
Street address 800 22nd St NW SEH 8850
City Washington
State/province DC
ZIP/Postal code 20052
Country USA
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (12)
GSM1812033 K562-KDM2B
GSM1812034 K562-input
GSM1812035 REH-KDM2B
This SubSeries is part of SuperSeries:
GSE70729 Role of the histone demethylase KDM2B in hematopoietic homeostasis and malignancies
BioProject PRJNA289206
SRA SRP060509

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Supplementary file Size Download File type/resource
GSE70624_RAW.tar 1.1 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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