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Series GSE7035 Query DataSets for GSE7035
Status Public on Apr 19, 2007
Title Synergy between PPARgamma ligands and platinum-based drugs in cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary PPARγ is a member of the nuclear receptor family for which agonist ligands have anti-growth effects. However, clinical studies using PPARγ ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARγ activation with chemotherapeutic agents in current use for specific cancers. We observed a striking synergy between rosiglitazone and platinum-based drugs in several different cancers both in vitro and using transplantable and chemically induced “spontaneous” tumor models. The effect appears to be due in part to PPARγ-mediated downregulation of metallothioneins, proteins that have been shown to be involved in resistance to platinum-based therapy. These data strongly suggest combining PPARγ agonists and platinum-based drugs for the treatment of certain human cancers
Keywords: Gene expression, change, synergy of interaction
Overall design Cells were treated with either DMSO/control, rosiglitazone, carboplatin or combination or rosiglitazone and carboplatin in duplicate for 24 hr. RNA was isolated and microarray analysis carried out by the Dana-Farber Cancer Institute Microarray Core.
Contributor(s) Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM
Citation(s) 17482130
Submission date Feb 14, 2007
Last update date Aug 10, 2018
Contact name Geoffrey Girnun
Organization name Dana-Farber Cancer Institute
Department Cancer Biology
Street address One Jimmy Fund Way
City Boston
State/province MA
ZIP/Postal code 02115
Country USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (8)
GSM162889 Control treated cells Rep1
GSM162890 Control treated cells Rep2
GSM162891 Rosiglitazone treated cells Rep1
BioProject PRJNA98343

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Supplementary file Size Download File type/resource
GSE7035_RAW.tar 28.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data provided as supplementary file

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